Welcome

The Bukrinsky lab investigates the interactions between HIV and cholesterol, including the effects of HIV protein Nef on cholesterol homeostasis and the mechanisms behind the effects of genes regulating cholesterol metabolism on HIV replication, latency, and pathogenesis. We focus on the role of HIV-induced changes in cholesterol metabolism in HIV-associated co-morbidities, such as cardio-vascular disease and neurocognitive impairment. The lab uses a wide range of approaches, including proteomics and lipidomics, flow cytometry, confocal microscopy and image analysis, real-time PCR.