Publications

2025

Nef mediates neuroimmune response, myelin impairment, and neuronal injury in EcoHIV-infected mice
Jessica K Schenck, Cheryl Clarkson-Paredes, Tatiana Pushkarsky, Yongsen Wang, Robert H Miller, Michael I Bukrinsky 
Life Sci Alliance . 2024 Nov 12;8(2):e202402879. doi: 10.26508/lsa.202402879. Print 2025 Feb.

2024

HIV-1 Nef is carried on the surface of extracellular vesicles
Christophe Vanpouille, Beda Brichacek, Tatiana Pushkarsky, Larisa Dubrovsky, Wendy Fitzgerald, Nigora Mukhamedova, Sofia Garcia-Hernandez, Doreen Matthies, Anastas Popratiloff, Dmitri Sviridov, Leonid Margolis, Michael Bukrinsky
J Extracell Vesicles . 2024 Jul;13(7):e12478. doi: 10.1002/jev2.12478.

Extracellular vesicles produced by HIV-1 Nef-expressing cells induce myelin impairment and oligodendrocyte damage in the mouse central nervous system
Jessica K Schenck, Molly T Karl, Cheryl Clarkson-Paredes, Ashley Bastin, Tatiana Pushkarsky, Beda Brichacek, Robert H Miller, Michael I Bukrinsky 
J Neuroinflammation . 2024 May 13;21(1):127. doi: 10.1186/s12974-024-03124-5.

An Old Drug Learning New Tricks: A REPRIEVE for Cardiovascular Disease in HIV Infection
Dmitri Sviridov, Michael Bukrinsky
Clin Chem . 2024 May 2;70(5):690-692. doi: 10.1093/clinchem/hvad204.

Mpox (Monkeypox) Virus and Its Co-Infection with HIV, Sexually Transmitted Infections, or Bacterial Superinfections: Double Whammy or a New Prime Culprit?
Benjamin M Liu, Natella Y Rakhmanina Zhilong Yang, Michael I Bukrinsky  
Viruses. 2024 May 15;16(5):784. doi: 10.3390/v16050784.

2023

Neuro-HIV-New insights into pathogenesis and emerging therapeutic targets
Dmitri Sviridov, Michael Bukrinsky
FASEB J . 2023 Dec;37(12):e23301. doi: 10.1096/fj.202301239RR.

Editorial: Lipids and inflammation in health and disease, volume II 
Evgeny Bezsonov, Mirza S Baig, Michael Bukrinsky, Veronika Myasoedova, Alessio Ravani, Vasily Sukhorukov, Dongwei Zhang, Victoria Khotina, Alexander Orekhov
Front Cardiovasc Med. 2023 Apr 12:10:1174902. doi: 10.3389/fcvm.2023.1174902. eCollection 2023.

2022

Trained Immunity and HIV Infection. 
Dmitri Sviridov, Yury I Miller, Michael I Bukrinsky 
Front Immunol. 2022 Jul 8:13:903884. doi: 10.3389/fimmu.2022.903884. eCollection 2022.

Extracellular vesicles carrying HIV-1 Nef induce long-term hyperreactivity of myeloid cells 
Larisa Dubrovsky, Beda Brichacek, N M Prashant, Tatiana Pushkarsky, Nigora Mukhamedova, Andrew J Fleetwood, Yangsong Xu, Dragana Dragoljevic, Michael Fitzgerald, Anelia Horvath, Andrew J Murphy, Dmitri Sviridov, Michael I Bukrinsky
Cell Rep. 2022 Nov 22;41(8):111674. doi: 10.1016/j.celrep.2022.111674.

Editorial: Lipids and Inflammation in Health and Disease
Evgeny Bezsonov, Vasily Sukhorukov, Michael Bukrinsky, Alexander Orekhov
 Front Cardiovasc Med. 2022 Mar 15:9:864429. doi: 10.3389/fcvm.2022.864429. eCollection 2022.

Abundance of Nef and p-Tau217 in Brains of Individuals Diagnosed with HIV-Associated Neurocognitive Disorders Correlate with Disease Severance
Tatiana Pushkarsky, Adam Ward, Andrey Ivanov, Xionghao Lin, Dmitri Sviridov, Sergei Nekhai, Michael I Bukrinsky 
Mol Neurobiol. 2022 Feb;59(2):1088-1097. doi: 10.1007/s12035-021-02608-2. Epub 2021 Nov 29.

2021

Direct interaction between ABCA1 and HIV-1 Nef: Molecular modeling and virtual screening for inhibitors
Alexei A Adzhubei, Amol Kulkarni, Anna P Tolstova, Anastasia A Anashkina, Dmitri Sviridov, Alexander A Makarov, Michael I Bukrinsky
Comput Struct Biotechnol J. 2021 Jul 1:19:3876-3884. doi: 10.1016/j.csbj.2021.06.050. eCollection 2021.

Non-linear optical imaging of atherosclerotic plaques in the context of SIV and HIV infection prominently detects crystalline cholesterol esters
Min Hi Park , Jeffrey L Suhalim, Firas Elmastour, Santu K Singha, Tadashi Imafuku, Ramanathan Venkatnarayan, Anette Christ , Alena Grebe, Sarah A Oppelt, Dmitri Sviridov, Michael Bukrinsky, Eicke Latz, Eric O Potma , Michael L Fitzgerald 
PLoS One. 2021 May 13;16(5):e0251599. doi: 10.1371/journal.pone.0251599. eCollection 2021.

2020

Comorbidities of HIV infection: role of Nef-induced impairment of cholesterol metabolism and lipid raft functionality 
Dmitri Sviridov, Nigora Mukhamedova, Alexander A Makarov, Alexei Adzhubei, Michael Bukrinsky
AIDS. 2020 Jan 1;34(1):1-13. doi: 10.1097/QAD.0000000000002385.

Editorial On "Exosomes, Their Biogenesis and Role in Inter-Cellular Communication, Tumor Microenvironment and Cancer Immunotherapy" 
Vita Golubovskaya, Michael I Bukrinsky, Fabio Grizzi 
Vaccines (Basel). 2020 Jul 28;8(3):421. doi: 10.3390/vaccines8030421.

Lipid rafts and pathogens: the art of deception and exploitation 
Michael I Bukrinsky, Nigora Mukhamedova, Dmitri Sviridov 
J Lipid Res. 2020 May;61(5):601-610. doi: 10.1194/jlr.TR119000391. Epub 2019 Oct 15.

Targeting Lipid Rafts-A Potential Therapy for COVID-19
Dmitri Sviridov 1 2, Yury I Miller 3, Rami A Ballout 4, Alan T Remaley 4, Michael Bukrinsky 5 
2020 Sep 29:11:574508. doi: 10.3389/fimmu.2020.574508. eCollection 2020.

Fingolimod inhibits multiple stages of the HIV-1 life cycle
Rachel S Resop, Rémi Fromentin, Daniel Newman, Hawley Rigsby, Larisa Dubrovsky, Michael Bukrinsky, Nicolas Chomont, Alberto Bosque
PLoS Pathog. 2020 Aug 13;16(8):e1008679. doi: 10.1371/journal.ppat.1008679. eCollection 2020 Aug.

Inhibition of HIV Replication by Apolipoprotein A-I Binding Protein Targeting the Lipid Rafts
Larisa Dubrovsky, Adam Ward, Soo-Ho Choi, Tatiana Pushkarsky, Beda Brichacek, Christophe Vanpouille, Alexei A Adzhubei, Nigora Mukhamedova, Dmitri Sviridov, Leonid Margolis, Richard B Jones, Yury I Miller, Michael Bukrinsky  
mBio. 2020 Jan 21;11(1):e02956-19. doi: 10.1128/mBio.02956-19.

Cholesterol Efflux-Independent Modification of Lipid Rafts by AIBP (Apolipoprotein A-I Binding Protein)
Hann Low, Nigora Mukhamedova, Luciano Dos Santos Aggum Capettini, Yining Xia, Irena Carmichael, Stephen H Cody, Kevin Huynh, Michael Ditiatkovski, Ryunosuke Ohkaw , Michael Bukrinsky , Peter J Meikle, Soo-Ho Choi Seth Field, Yury I Miller, Dmitri Sviridov 
Arterioscler Thromb Vasc Biol. 2020 Oct;40(10):2346-2359. doi: 10.1161/ATVBAHA.120.315037. Epub 2020 Aug 13.

CBF-1 Promotes the Establishment and Maintenance of HIV Latency by Recruiting Polycomb Repressive Complexes, PRC1 and PRC2, at HIV LTR
Adhikarimayum Lakhikumar Sharma, Joseph Hokello, Shilpa Sonti, Sonia Zicari Lin Sun, Aseel Alqatawni, Michael Bukrinsky, Gary Simon, Ashok Chauhan, Rene Daniel, Mudit Tyagi
Viruses. 2020 Sep 18;12(9):1040. doi: 10.3390/v12091040.

Modification of lipid rafts by extracellular vesicles carrying HIV-1 protein Nef induces redistribution of amyloid precursor protein and Tau, causing neuronal dysfunction
Michael Ditiatkovski, Nigora Mukhamedova, Dragana Dragoljevic, Anh Hoang, Hann Low, Tatiana Pushkarsky, Ying Fu, Irena Carmichael, Andrew F Hill, Andrew J Murphy, Michael Bukrinsky, Dmitri Sviridov
J Biol Chem. 2020 Sep 18;295(38):13377-13392. doi: 10.1074/jbc.RA120.014642. Epub 2020 Jul 30.

The lysosome: A potential juncture between SARS-CoV-2 infectivity and Niemann-Pick disease type C, with therapeutic implications
Rami A Ballout, Dmitri Sviridov, Michael I Bukrinsky, Alan T Remaley 
FASEB J. 2020 Jun;34(6):7253-7264. doi: 10.1096/fj.202000654R. Epub 2020 May 5.

Erratum for Dubrovsky et al., "Inhibition of HIV Replication by Apolipoprotein A-I Binding Protein Targeting the Lipid Rafts"
Larisa Dubrovsky, Adam Ward, Soo-Ho Choi, Tatiana Pushkarsky, Beda Brichacek, Christophe Vanpouille, Alexei A Adzhubei, Nigora Mukhamedova, Dmitri Sviridov, Leonid Margolis, Richard B Jones, Yury I Miller, Michael Bukrinsky
mBio. 2020 Mar 17;11(2):e00234-20. doi: 10.1128/mBio.00234-20.

DNA dependent protein kinase (DNA-PK) enhances HIV transcription by promoting RNA polymerase II activity and recruitment of transcription machinery at HIV LTR
Sonia Zicari 1 2 3 4, Adhikarimayum Lakhikumar Sharma 1 4, Geetaram Sahu 5 4, Larisa Dubrovsky 6, Lin Sun 5, Han Yue 5, Tejaswi Jada 5, Alex Ochem 7, Gary Simon 5, Michael Bukrinsky 6, Mudit Tyagi 1 
Oncotarget. 2020 Feb 18;11(7):699-726. doi: 10.18632/oncotarget.27487.

2019

HIV disease, metabolic dysfunction and atherosclerosis: A three year prospective study
Hann Low, Anh Hoang, Tatiana Pushkarsky, Larisa Dubrovsky, Elizabeth Dewar, Maria-Silvana Di Yacovo, Nigora Mukhamedova, Lesley Cheng, Catherine Downs, Gary Simon, Maria Saumoy, Andrew F Hill, Michael L Fitzgerald, Paul Nestel, Anthony Dart, Jennifer Hoy, Michael Bukrinsky, Dmitri Sviridov
PLoS One. 2019 Apr 18;14(4):e0215620. doi: 10.1371/journal.pone.0215620. eCollection 2019.

Exosomes containing HIV protein Nef reorganize lipid rafts potentiating inflammatory response in bystander cells
Nigora Mukhamedova, Anh Hoang, Dragana Dragoljevic, Larisa Dubrovsky, Tatiana Pushkarsky, Hann Low, Michael Ditiatkovski, Ying Fu, Ryunosuke Ohkawa, Peter J Meikle, Anelia Horvath, Beda Brichacek, Yury I Miller, Andrew Murphy, Michael Bukrinsky, Dmitri Sviridov 
PLoS Pathog. 2019 Jul 25;15(7):e1007907. doi: 10.1371/journal.ppat.1007907. eCollection 2019 Jul.

Listeria monocytogenes hijacks CD147 to ensure proper membrane protrusion formation and efficient bacterial dissemination
Aaron S Dhanda, Katarina T Lulic, Connie Yu, Robert H Chiu, Michael Bukrinsky, Julian A Guttman 
Cell Mol Life Sci. 2019 Oct;76(20):4165-4178. doi: 10.1007/s00018-019-03130-4. Epub 2019 May 10.

2018

Modelling interaction between HIV-1 Nef and calnexin
Alexei A Adzhubei, Anastasia A Anashkina, Yaroslav V Tkachev, Yury V Kravatsky, Tatiana Pushkarsky, Amol Kulkarni, Alexander A Makarov, Michael I Bukrinsky
AIDS . 2018 Sep 24;32(15):2103-2111. doi: 10.1097/QAD.0000000000001951.

Atherosclerosis in subjects newly diagnosed with human immunodeficiency virus infection
Tatiana V Kirichenko, Veronika A Myasoedova, Tatiana E Shimonova, Alexandra A Melnichenko, Dmitri Sviridov, Igor A Sobenin, Alexey I Mazus, Alexander N Orekhov, Michael I Bukrinsky
Biosci Rep. 2018 Jul 18;38(4):BSR20180597. doi: 10.1042/BSR20180597. Print 2018 Aug 31.

Modified LDL Particles Activate Inflammatory Pathways in Monocyte-derived Macrophages: Transcriptome Analysis
Alexander N Orekhov, Yumiko Oishi, Nikita G Nikiforov, Andrey V Zhelankin, Larisa Dubrovsky, Igor A Sobenin, Alexander Kel, Daria Stelmashenko, Vsevolod J Makeev, Kathy Foxx, Xueting Jin, Howard S Kruth, Michael Bukrinsky 
Curr Pharm Des. 2018;24(26):3143-3151. doi: 10.2174/1381612824666180911120039.

HDL activates expression of genes stimulating cholesterol efflux in human monocyte-derived macrophages
Alexander N Orekhov, Tatiana Pushkarsky, Yumiko Oishi, Nikita G Nikiforov, Andrey V Zhelankin, Larisa Dubrovsky, Vsevolod J Makeev, Kathy Foxx, Xueting Jin, Howard S Kruth, Igor A Sobenin, Vasily N Sukhorukov, Emile R Zakiev, Anatol Kontush, Wilfried Le Goff, Michael Bukrinsky 
Exp Mol Pathol. 2018 Oct;105(2):202-207. doi: 10.1016/j.yexmp.2018.08.003. Epub 2018 Aug 16.

2017

Yeast help identify cytopathic factors of Zika virus
Michael Bukrinsky
Cell Biosci. 2017 Feb 20:7:12. doi: 10.1186/s13578-017-0139-5. eCollection 2017.

Short Communication: Accumulation of Neutral Lipids in Liver and Aorta of Nef-Transgenic Mice
Tatiana Pushkarsky, Evgeny Shilov, Natalya Kruglova, Ronald Naumann, Beda Brichacek, Lucas Jennelle, Dmitri Sviridov, Andrei Kruglov, Sergei A Nedospasov, Michael Bukrinsky 
AIDS Res Hum Retroviruses. 2017 Jan;33(1):57-60. doi: 10.1089/AID.2016.0128. Epub 2016 Oct 25.

Association of a 3' untranslated region polymorphism in proprotein convertase subtilisin/kexin type 9 with HIV viral load and CD4+ levels in HIV/hepatitis C virus coinfected women
Mark H Kuniholm, Hua Liang, Kathryn Anastos, Deborah Gustafson, Seble Kassaye, Marek Nowicki, Beverly E Sha, Emilia J Pawlowski, Stephen J Gange, Bradley E Aouizerat, Tatiana Pushkarsky, Michael I Bukrinsky, Vinayaka R Prasad 
AIDS. 2017 Nov 28;31(18):2483-2492. doi: 10.1097/QAD.0000000000001648.

Use of Primary Macrophages for Searching Novel Immunocorrectors
Nikita G Nikiforov, Natalia V Elizova, Michael Bukrinsky, Larisa Dubrovsky, Vsevolod J Makeev, Yoshiyuki Wakabayashi 4, Poching Liu, Kathy K Foxx, Howard S Kruth, Xueting Jin, Emile R Zakiev, Alexander N Orekhov  
Curr Pharm Des. 2017;23(6):915-920. doi: 10.2174/1381612823666170125110128.

2016

Mechanisms of HIV Transcriptional Regulation by Drugs of Abuse
Mudit Tyagi 1, Michael Bukrinsky, Gary L Simon 
Curr HIV Res. 2016;14(5):442-454. doi: 10.2174/1570162x14666160324124736.

Analysis of ABCA1 and Cholesterol Efflux in HIV-Infected Cells
Nigora Mukhamedova, Beda Brichacek, Christina Darwish, Anastas Popratiloff, Dmitri Sviridov, Michael Bukrinsky 
Methods Mol Biol. 2016:1354:281-92. doi: 10.1007/978-1-4939-3046-3_19.

Live Cell Imaging of ABCA1 Downregulation by HIV-1 Nef in an Experimental Model of HeLa ABCA1-GFP
Johanna Siegel, Christina Darwish, Anastas Popratiloff, Michael Bukrinsky, Beda Brichacek 
AIDS Res Hum Retroviruses. 2016 Sep;32(9):872-3. doi: 10.1089/aid.2015.0362. Epub 2016 May 2.

Cytomegalovirus Restructures Lipid Rafts via a US28/CDC42-Mediated Pathway, Enhancing Cholesterol Efflux from Host Cells
Hann Low, Nigora Mukhamedova, Huanhuan L Cui, Brian P McSharry, Selmir Avdic, Anh Hoang, Michael Ditiatkovski, Yingying Liu, Ying Fu, Peter J Meikle, Martin Blomberg, Konstantinos A Polyzos, William E Miller, Piotr Religa, Michael Bukrinsky, Cecilia Soderberg-Naucler, Barry Slobedman, Dmitri Sviridov 
Cell Rep. 2016 Jun 28;16(1):186-200. doi: 10.1016/j.celrep.2016.05.070. Epub 2016 Jun 16.

Lipid metabolism in patients infected with Nef-deficient HIV-1 strain
Hann Low, Lesley Cheng, Maria-Silvana Di Yacovo, Melissa J Churchill, Peter Meikle, Michael Bukrinsky, Andrew F Hill, Dmitri Sviridov
Atherosclerosis. 2016 Jan:244:22-8. doi: 10.1016/j.atherosclerosis.2015.10.103. Epub 2015 Oct 30. 

Cold Atmospheric Plasma Inhibits HIV-1 Replication in Macrophages by Targeting Both the Virus and the Cells
Olga Volotskova 1, Larisa Dubrovsky 2, Michael Keidar 1, Michael Bukrinsky 
PLoS One. 2016 Oct 26;11(10):e0165322. doi: 10.1371/journal.pone.0165322. eCollection 2016.

HIV-1 Integrates Widely throughout the Genome of the Human Blood Fluke Schistosoma mansoni
Sutas Suttiprapa, Gabriel Rinaldi, Isheng J Tsai 4 5, Victoria H Mann, Larisa Dubrovsky, Hong-Bin Yan, Nancy Holroyd, Thomas Huckvale, Caroline Durrant, Anna V Protasio, Tatiana Pushkarsky, Sergey Iordanskiy, Matthew Berriman, Michael I Bukrinsky, Paul J Brindley 
PLoS Pathog. 2016 Oct 20;12(10):e1005931. doi: 10.1371/journal.ppat.1005931. eCollection 2016 Oct.

Small GTPase ARF6 Regulates Endocytic Pathway Leading to Degradation of ATP-Binding Cassette Transporter A1
Nigora Mukhamedova, Anh Hoang, Huanhuan L Cui, Irena Carmichael, Ying Fu, Michael Bukrinsky, Dmitri Sviridov 
Arterioscler Thromb Vasc Biol. 2016 Dec;36(12):2292-2303. doi: 10.1161/ATVBAHA.116.308418. Epub 2016 Oct 6.

Interaction Between HIV-1 Nef and Calnexin: From Modeling to Small Molecule Inhibitors Reversing HIV-Induced Lipid Accumulation
Ruth Hunegnaw, Marina Vassylyeva, Larisa Dubrovsky, Tatiana Pushkarsky, Dmitri Sviridov, Anastasia A Anashkina, Aykut Üren, Beda Brichacek, Dmitry G Vassylyev, Alexei A Adzhubei, Michael Bukrinsky 
Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):1758-71. doi: 10.1161/ATVBAHA.116.307997. Epub 2016 Jul 28.

Cellular minichromosome maintenance complex component 5 (MCM5) is incorporated into HIV-1 virions and modulates viral replication in the newly infected cells
Steven Santos, Yuri Obukhov , Sergei Nekhai, Tatiana Pushkarsky, Beda Brichacek, Michael Bukrinsky, Sergey Iordanskiy 
Virology. 2016 Oct:497:11-22. doi: 10.1016/j.virol.2016.06.023. Epub 2016 Jul 12.
 

2015

The effects of cocaine on HIV transcription.
Tyagi M, Weber J, Bukrinsky M, Simon GL.
J Neurovirol. 2015 Nov 16. [Epub ahead of print]

HIV infection induces structural and functional changes in high density lipoproteins.
Siegel MO, Borkowska AG, Dubrovsky L, Roth M, Welti R, Roberts AD, Parenti DM, Simon GL, Sviridov D, Simmens S, Bukrinsky M, Fitzgerald ML.
Atherosclerosis. 2015 Nov;243(1):19-29.

Lipid metabolism in patients infected with Nef-deficient HIV-1 strain.
Low H, Cheng L, Di Yacovo MS, Churchill MJ, Meikle P, Bukrinsky M, Hill AF, Sviridov D.
Atherosclerosis. 2015 Oct 30;244:22-28. 

Extracellular cyclophilins in health and disease.
Bukrinsky M.
Biochim Biophys Acta. 2015 Oct;1850(10):2087-95. Review.

Stimulation of Liver X Receptor Has Potent Anti-HIV Effects in a Humanized Mouse Model of HIV Infection.
Ramezani A, Dubrovsky L, Pushkarsky T, Sviridov D, Karandish S, Raj DS, Fitzgerald ML, Bukrinsky M.
J Pharmacol Exp Ther. 2015 Sep;354(3):376-83.

Targeting extracellular cyclophilins ameliorates disease progression in experimental biliary atresia.
Iordanskaia T, Malesevic M, Fischer G, Pushkarsky T, Bukrinsky M, Nadler E.
Mol Med. 2015 Jul 24.

Inhibition of extracellular cyclophilins with cyclosporine analog and development of atherosclerosis in apolipoprotein e-deficient mice.
Ditiatkovski M, Neelisetti VN, Cui HL, Malesevic M, Fischer G, Bukrinsky M, Sviridov D.
J Pharmacol Exp Ther. 2015 Jun;353(3):490-5.

Jan van der Noordaa (1934-2015); A Virologist Pur Sang
Ben Berkhout 1, Michael Bukrinsky 2 
Viruses. 2015 Sep 15;7(9):5016-7. doi: 10.3390/v7092859.

Lipidomic dataset of plasma from patients infected with wild type and nef-deficient HIV-1 strain
Peter Meikle 1, Hann Low 1, Melissa J Churchill 2, Michael Bukrinsky 3, Dmitri Sviridov 1
Data Brief. 2015 Dec 11:6:168-75. doi: 10.1016/j.dib.2015.11.067. eCollection 2016 Mar.
 

Top

2014

Bukrinsky M. 
Extracellular cyclophilins in health and disease.
Biochim Biophys Acta. 2014 Nov 18. pii: S0304-4165(14)00390-0. 

Jennelle L, Hunegnaw R, Dubrovsky L, Pushkarsky T, Fitzgerald ML, Sviridov D, Popratiloff A, Brichacek B, Bukrinsky M. 
HIV-1 protein Nef inhibits activity of ATP-binding cassette transporter A1 by targeting endoplasmic reticulum chaperone calnexin.
J Biol Chem. 2014 Oct 17;289(42):28870-84.

Brichacek B, Darwish C, Popratiloff A, Dubrovsky L, Bukrinsky M. 
HIV-1 infection of macrophages induces retention of cholesterol transporter ABCA1 in the endoplasmic reticulum.
AIDS Res Hum Retroviruses. 2014 Oct;30(10):947-8. 

Sviridov D, Bukrinsky M. 
Interaction of pathogens with host cholesterol metabolism.
Curr Opin Lipidol. 2014 Oct;25(5):333-8.

Cui HL, Ditiatkovski M, Kesani R, Bobryshev YV, Liu Y, Geyer M, Mukhamedova N, Bukrinsky M, Sviridov D.
HIV protein Nef causes dyslipidemia and formation of foam cells in mouse models of atherosclerosis.
FASEB J. 2014 Jul;28(7):2828-39.

Jacob D, Hunegnaw R, Sabyrzyanova TA, Pushkarsky T, Chekhov VO, Adzhubei AA, Kalebina TS, Bukrinsky M.
The ABCA1 domain responsible for interaction with HIV-1 Nef is conformational and not linear.
Biochem Biophys Res Commun. 2014 Jan31;444(1):19-23.

Cui HL, Guo B, Scicluna B, Coleman BM, Lawson VA, Ellett L, Meikle PJ, Bukrinsky M, Mukhamedova N, Sviridov D, Hill AF. 
Prion infection impairs cholesterol metabolism in neuronal cells.
J Biol Chem. 2014 Jan10;289(2):789-802

Zhao RY, Bukrinsky MI. 
HIV-1 accessory proteins: VpR.
Methods Mol Biol. 2014;1087:125-34

HIV-1 protein Nef inhibits activity of ATP-binding cassette transporter A1 by targeting endoplasmic reticulum chaperone calnexin
Lucas Jennelle, Ruth Hunegnaw, Larisa Dubrovsky, Tatiana Pushkarsky, Michael L Fitzgerald, Dmitri Sviridov, Anastas Popratiloff, Beda Brichacek, Michael Bukrinsky

J Biol Chem. 2014 Oct 17;289(42):28870-84. doi: 10.1074/jbc.M114.583591. Epub 2014 Aug 28.

New clues to understanding HIV nonprogressors: low cholesterol blocks HIV trans infection
Vinayaka R Prasad, Michael I Bukrinsky

mBio. 2014 Jun 10;5(3):e01396-14. doi: 10.1128/mBio.01396-14.

Top

2013

Iordanskiy S, Santos S, Bukrinsky M. 
Nature, nurture and HIV: The effect of producer cell on viral physiology.
Virology. 2013 Sep 1;443(2):208-13. Review.

Rose H, Low H, Dewar E, Bukrinsky M, Hoy J, Dart A, Sviridov D. 
The effect of HIV infection on atherosclerosis and lipoprotein metabolism: a one year prospective study.
Atherosclerosis. 2013 Jul;229(1):206-11.

Bukrinsky M, Orekhov A, Ditiatkovski M, Sviridov D. 
Cyclophilins in atherosclerosis: a new therapeutic target?
Curr Pharm Des. 2013;19(33):5904-8. Review.

Top

2012

Tyagi M, Bukrinsky M. 
Human immunodeficiency virus (HIV) latency: the major hurdle in HIV eradication.
Mol Med. 2012 Sep 25;18:1096-108.

Santos S, Obukhov Y, Nekhai S, Bukrinsky M, Iordanskiy S. 
Virus-producing cells determine the host protein profiles of HIV-1 virion cores.
Retrovirology. 2012 Aug 13;9:65.

Cui HL, Grant A, Mukhamedova N, Pushkarsky T, Jennelle L, Dubrovsky L, Gaus K, Fitzgerald ML, Sviridov D, Bukrinsky M. 
HIV-1 Nef mobilizes lipid rafts in macrophages through a pathway that competes with ABCA1-dependent cholesterol efflux.
J Lipid Res. 2012 Apr;53(4):696-708.

Dubrovsky L, Van Duyne R, Senina S, Guendel I, Pushkarsky T, Sviridov D, Kashanchi F, Bukrinsky M. 
Liver X receptor agonist inhibits HIV-1 replication and prevents HIV-induced reduction of plasma HDL in humanized mouse model of HIV infection.
Biochem Biophys Res Commun. 2012 Mar 2;419(1):95-8.

Top

2011

Stemmy EJ, Balsley MA, Jurjus RA, Damsker JM, Bukrinsky MI, Constant SL.
Blocking cyclophilins in the chronic phase of asthma reduces the persistence of leukocytes and disease reactivation.
Am J Respir Cell Mol Biol. 2011 Nov;45(5):991-8.

Trachtenberg A, Pushkarsky T, Heine S, Constant S, Brichacek B, Bukrinsky M. 
The level of CD147 expression correlates with cyclophilin-induced signaling and chemotaxis.
BMC Res Notes. 2011 Oct 11;4:396.

Levin A, Loyter A, Bukrinsky M. 
Strategies to inhibit viral protein nuclear import: HIV-1 as a target.
Biochim Biophys Acta. 2011 Sep;1813(9):1646-53. Review.

Zhao RY, Li G, Bukrinsky MI. 
Vpr-host interactions during HIV-1 viral life cycle.
J Neuroimmune Pharmacol. 2011 Jun;6(2):216-29. Review.

Heine SJ, Olive D, Gao JL, Murphy PM, Bukrinsky MI, Constant SL.
Cyclophilin A cooperates with MIP-2 to augment neutrophil migration.
J Inflamm Res. 2011;4:93-104

Top

2010

Balsley MA, Malesevic M, Stemmy EJ, Gigley J, Jurjus RA, Herzog D, Bukrinsky MI, Fischer G, Constant SL. 
A cell-impermeable cyclosporine A derivative reduces pathology in a mouse model of allergic lung inflammation.
J Immunol. 2010 Dec15;185(12):7663-70.

Mujawar Z, Tamehiro N, Grant A, Sviridov D, Bukrinsky M, Fitzgerald ML.
Mutation of the ATP cassette binding transporter A1 (ABCA1) C-terminus disrupts HIV-1 Nef binding but does not block the Nef enhancement of ABCA1 protein degradation.
Biochemistry. 2010 Sep 28;49(38):8338-49.

Asztalos BF, Mujawar Z, Morrow MP, Grant A, Pushkarsky T, Wanke C, Shannon R, Geyer M, Kirchhoff F, Sviridov D, Fitzgerald ML, Bukrinsky M, Mansfield KG.
Circulating Nef induces dyslipidemia in simian immunodeficiency virus-infected macaques by suppressing cholesterol efflux.
J Infect Dis. 2010 Aug15;202(4):614-23

Morrow MP, Grant A, Mujawar Z, Dubrovsky L, Pushkarsky T, Kiselyeva Y, Jennelle L, Mukhamedova N, Remaley AT, Kashanchi F, Sviridov D, Bukrinsky M.
Stimulation of the liver X receptor pathway inhibits HIV-1 replication via induction of ATP-binding cassette transporter A1.
Mol Pharmacol. 2010 Aug;78(2):215-25.

Li G, Elder RT, Dubrovsky L, Liang D, Pushkarsky T, Chiu K, Fan T, Sire J, Bukrinsky M, Zhao RY. 
HIV-1 replication through hHR23A-mediated interaction of Vpr with 26S proteasome.
PLoS One. 2010 Jun 29;5(6):e11371.

Yurchenko V, Constant S, Eisenmesser E, Bukrinsky M. 
Cyclophilin-CD147 interactions: a new target for anti-inflammatory therapeutics.
Clin Exp Immunol. 2010 Jun;160(3):305-17. Review.

Weinstein RS, Weinstein MM, Alibek K, Bukrinsky MI, Brichacek B.
Significantly reduced CCR5-tropic HIV-1 replication in vitro in cells from subjects previously immunized with Vaccinia Virus.
BMC Immunol. 2010 May 18;11:23.

Crowe SM, Westhorpe CL, Mukhamedova N, Jaworowski A, Sviridov D, Bukrinsky M.
The macrophage: the intersection between HIV infection and atherosclerosis. 
J Leukoc Biol. 2010 Apr;87(4):589-98. Review.

Malesević M, Kühling J, Erdmann F, Balsley MA, Bukrinsky MI, Constant SL, Fischer G. 
A cyclosporin derivative discriminates between extracellular and intracellular cyclophilins.
Angew Chem Int Ed Engl. 2010;49(1):213-5.

Strategies to inhibit viral protein nuclear import: HIV-1 as a target
Aviad Levin 1, Abraham Loyter, Michael Bukrinsky
Biochim Biophys Acta. 2011 Sep;1813(9):1646-53. doi: 10.1016/j.bbamcr.2010.07.010. Epub 2010 Aug 16.

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2009

Mukhamedova N, Rose H, Cui HL, Grant A, Tchoua U, Dart A, Bukrinsky M, Sviridov D. 
Antiretroviral compounds and cholesterol efflux from macrophages.
Atherosclerosis. 2009 Oct;206(2):439-43.

Schlegel J, Redzic JS, Porter CC, Yurchenko V, Bukrinsky M, Labeikovsky W, Armstrong GS, Zhang F, Isern NG, DeGregori J, Hodges R, Eisenmesser EZ. 
Solution characterization of the extracellular region of CD147 and its interaction with its enzyme ligand cyclophilin A.
J Mol Biol. 2009 Aug 21;391(3):518-35.

Li G, Bukrinsky M, Zhao RY. 
HIV-1 viral protein R (Vpr) and its interactions with host cell.
Curr HIV Res. 2009 Mar;7(2):178-83. Review.

Abbadessa G, Accolla R, Aiuti F, Albini A, Aldovini A, Alfano M, Antonelli G, Bartholomew C, Bentwich Z, Bertazzoni U, Berzofsky JA, Biberfeld P, Boeri E, Buonaguro L, Buonaguro FM, Bukrinsky M, Burny A, Caruso A, Cassol S, Chandra P, Ceccherini-Nelli L, Chieco-Bianchi L, Clerici M, Colombini-Hatch S, de Giuli Morghen C, de Maria A, de Rossi A, Dierich M, Della-Favera R, Dolei A, Douek D, Erfle V, Felber B, Fiorentini S, Franchini G, Gershoni JM, Gotch F, Green P, Greene WC, Hall W, Haseltine W, Jacobson S, Kallings LO, Kalyanaraman VS, Katinger H, Khalili K, Klein G, Klein E, Klotman M, Klotman P, Kotler M, Kurth R, Lafeuillade A, La Placa M, Lewis J, Lillo F, Lisziewicz J, Lomonico A, Lopalco L, Lori F, Lusso P, Macchi B, Malim M, Margolis L, Markham PD, McClure M, Miller N, Mingari MC, Moretta L, Noonan D, O'Brien S, Okamoto T, Pal R, Palese P, Panet A, Pantaleo G, Pavlakis G, Pistello M, Plotkin S, Poli G, Pomerantz R, Radaelli A, Robertguroff M, Roederer M, Sarngadharan MG, Schols D, Secchiero P, Shearer G, Siccardi A, Stevenson M, Svoboda J, Tartaglia J, Torelli G, Tornesello ML, Tschachler E, Vaccarezza M, Vallbracht A, van Lunzen J, Varnier O, Vicenzi E, von Melchner H, Witz I, Zagury D, Zagury JF, Zauli G, Zipeto D. 
Unsung hero Robert C. Gallo.
Science. 2009 Jan 9;323(5911):206-7.

Kadiu I, Wang T, Schlautman JD, Dubrovsky L, Ciborowski P, Bukrinsky M, Gendelman HE.
HIV-1 transforms the monocyte plasma membrane proteome.
Cell Immunol. 2009;258(1):44-58.

Damsker JM, Okwumabua I, Pushkarsky T, Arora K, Bukrinsky MI, Constant SL.
Targeting the chemotactic function of CD147 reduces collagen-induced arthritis.
Immunology. 2009 Jan;126(1):55-62.

Iordanskiy SN, Bukrinsky MI. 
Analysis of viral and cellular proteins in HIV-1 reverse transcription complexes by co-immunoprecipitation.
Methods Mol Biol. 2009;485:121-34.

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2008

Mukhamedova N, Escher G, D'Souza W, Tchoua U, Grant A, Krozowski Z, Bukrinsky M, Sviridov D. 
Enhancing apolipoprotein A-I-dependent cholesterol efflux elevates cholesterol export from macrophages in vivo.
J Lipid Res. 2008 Nov;49(11):2312-22.

Bukrinsky M. 
How to engage Cofilin.
Retrovirology. 2008 Sep 22; 5:85.

Rose H, Hoy J, Woolley I, Tchoua U, Bukrinsky M, Dart A, Sviridov D. 
HIV infection and high density lipoprotein metabolism.
Atherosclerosis. 2008 Jul;199(1):79-86.

Yurchenko V, Xue Z, Sherry B, Bukrinsky M. 
Functional analysis of Leishmania major cyclophilin.
Int J Parasitol. 2008 May;38(6):633-9.

Wu W, Kehn-Hall K, Pedati C, Zweier L, Castro I, Klase Z, Dowd CS, Dubrovsky L, Bukrinsky M, Kashanchi F. 
Drug 9AA reactivates p21/Waf1 and Inhibits HIV-1 progeny formation.
Virol J. 2008 Mar 18;5:41.

Targeting the chemotactic function of CD147 reduces collagen-induced arthritis
Jesse M Damsker, Ifeanyi Okwumabua, Tatiana Pushkarsky, Kamalpreet Arora, Michael I Bukrinsky, Stephanie L Constant 
Immunology. 2009 Jan;126(1):55-62. doi: 10.1111/j.1365-2567.2008.02877.x. Epub 2008 Jun 14.
 

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2007

Pushkarsky T, Yurchenko V, Laborico A, Bukrinsky M. 
CD147 stimulates HIV-1 infection in a signal-independent fashion.
Biochem Biophys Res Commun. 2007 Nov 23;363(3):495-9.

Damsker JM, Bukrinsky MI, Constant SL. 
Preferential chemotaxis of activated human CD4+ T cells by extracellular cyclophilin A.
J Leukoc Biol. 2007 Sep;82(3):613-8.

Mukhamedova N, Fu Y, Bukrinsky M, Remaley AT, Sviridov D. 
The role of different regions of ATP-binding cassette transporter A1 in cholesterol efflux.
Biochemistry. 2007 Aug 21;46(33):9388-98.

Liang D, Benko Z, Agbottah E, Bukrinsky M, Zhao RY. 
Anti-vpr activities of heat shock protein 27.
Mol Med. 2007 May-Jun;13(5-6):229-39.

Benko Z, Liang D, Agbottah E, Hou J, Taricani L, Young PG, Bukrinsky M, Zhao RY. 
Antagonistic interaction of HIV-1 Vpr with Hsf-mediated cellular heat shock response and Hsp16 in fission yeast (Schizosaccharomyces pombe).
Retrovirology. 2007 Mar 7;4:16.

Zhao RY, Elder RT, Bukrinsky M. 
Interactions of HIV-1 viral protein R with host cell proteins.
Adv Pharmacol. 2007;55:233-60. Review.

Iordanskiy S, Bukrinsky M. 
Reverse transcription complex: the key player of the early phase of HIV replication.
Future Virol. 2007 Jan 1;2(1):49-64.

Bukrinsky M, Sviridov D. 
HIV and cardiovascular disease: contribution of HIV-infected macrophages to development of atherosclerosis.
PLoS Med. 2007 Jan;4(1):e43.

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2006

Bukrinsky M, Sviridov D.
Human immunodeficiency virus infection and macrophage cholesterol metabolism.
J Leukoc Biol. 2006 Nov;80(5):1044-51. Review.

Gwinn WM, Damsker JM, Falahati R, Okwumabua I, Kelly-Welch A, Keegan AD, Vanpouille C, Lee JJ, Dent LA, Leitenberg D, Bukrinsky MI, Constant SL. 
Novel approach to inhibit asthma-mediated lung inflammation using anti-CD147 intervention.
J Immunol. 2006 Oct 1;177(7):4870-9.

Mujawar Z, Rose H, Morrow MP, Pushkarsky T, Dubrovsky L, Mukhamedova N, Fu Y, Dart A, Orenstein JM, Bobryshev YV, Bukrinsky M, Sviridov D. 
Human immunodeficiency virus impairs reverse cholesterol transport from macrophages.
PLoS Biol. 2006 Oct;4(11):e365.

Brichacek B, Vanpouille C, Trachtenberg AJ, Pushkarsky T, Dubrovsky L, Martin G, Simon G, Bukrinsky M. 
Long-term changes of serum chemokine levels in vaccinated military personnel.
BMC Immunol. 2006 Sep 11;7:21.

Bukrinsky M. 
SNFing HIV transcription.
Retrovirology. 2006 Aug 9;3:49.

Yurchenko V, Constant S, Bukrinsky M. 
Dealing with the family: CD147 interactions with cyclophilins.
Immunology. 2006 Mar;117(3):301-9. Review.

Iordanskiy S, Berro R, Altieri M, Kashanchi F, Bukrinsky M.
Intracytoplasmic maturation of the human immunodeficiency virus type 1 reverse transcription complexes determines their capacity to integrate into chromatin.
Retrovirology. 2006 Jan 12;3:4.

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2005

Li L, Li HS, Pauza CD, Bukrinsky M, Zhao RY. 
Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions.
Cell Res. 2005 Nov-Dec;15(11-12):923-34. Review.

Haffar O, Dubrovsky L, Lowe R, Berro R, Kashanchi F, Godden J, Vanpouille C, Bajorath J, Bukrinsky M. 
Oxadiazols: a new class of rationally designed anti-human immunodeficiency virus compounds targeting the nuclear localization signal of the viral matrix protein.
J Virol. 2005 Oct;79(20):13028-36.

Pushkarsky T, Yurchenko V, Vanpouille C, Brichacek B, Vaisman I, Hatakeyama S, Nakayama KI, Sherry B, Bukrinsky MI. 
Cell surface expression of CD147/EMMPRIN is regulated by cyclophilin 60.
J Biol Chem. 2005 Jul 29;280(30):27866-71.

Arora K, Gwinn WM, Bower MA, Watson A, Okwumabua I, MacDonald HR, Bukrinsky MI, Constant SL. 
Extracellular cyclophilins contribute to the regulation of inflammatory responses.
J Immunol. 2005 Jul 1;175(1):517-22.

Yurchenko V, Pushkarsky T, Li JH, Dai WW, Sherry B, Bukrinsky M. 
Regulation of CD147 cell surface expression: involvement of the proline residue in the CD147 transmembrane domain.
J Biol Chem. 2005 Apr 29;280(17):17013-9.

Zhao RY, Bukrinsky M, Elder RT. 
HIV-1 viral protein R (Vpr) & host cellular responses.
Indian J Med Res. 2005 Apr;121(4):270-86. Review.

Haffar O, Bukrinsky M. 
Nuclear translocation as a novel target for anti-HIV drugs.
Expert Rev Anti Infect Ther. 2005 Feb;3(1):41-50. Review.

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2004

Benko Z, Liang D, Agbottah E, Hou J, Chiu K, Yu M, Innis S, Reed P, Kabat W, Elder RT, Di Marzio P, Taricani L, Ratner L, Young PG, Bukrinsky M, Zhao RY.
Anti-Vpr activity of a yeast chaperone protein.
J Virol. 2004 Oct;78(20):11016-29.

Iordanskiy S, Zhao Y, DiMarzio P, Agostini I, Dubrovsky L, Bukrinsky M.
Heat-shock protein 70 exerts opposing effects on Vpr-dependent and Vpr-independent HIV-1 replication in macrophages.
Blood. 2004 Sep15;104(6):1867-72.

Iordanskiy S, Zhao Y, Dubrovsky L, Iordanskaya T, Chen M, Liang D, Bukrinsky M. 
Heat shock protein 70 protects cells from cell cycle arrest and apoptosis induced by human immunodeficiency virus type 1 viral protein R.
J Virol. 2004 Sep;78(18):9697-704.

Bukrinsky M, Zhao Y. 
Heat-shock proteins reverse the G2 arrest caused by HIV-1 viral protein R.
DNA Cell Biol. 2004 Apr;23(4):223-5.

Bukrinsky M. 
A hard way to the nucleus.
Mol Med. 2004 Jan-Jun;10(1-6):1-5. Review.

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2003

Marzio PD, Sherry B, Thomas EK, Franchin G, Schmidtmayerova H, Bukrinsky M.
beta-Chemokine production in CD40L-stimulated monocyte-derived macrophages requires activation of MAPK signaling pathways.
Cytokine. 2003 Aug 7;23(3):53-63.

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2002

Al-Abed Y, Dubrovsky L, Ruzsicska B, Seepersaud M, Bukrinsky M.
Inhibition of HIV-1 nuclear import via schiff base formation with arylene bis(methylketone) compounds.
Bioorg Med Chem Lett. 2002 Nov 4;12(21):3117-9.

Brichacek B, Bukrinsky M. 
Highly active antiretroviral therapy and beta-chemokines.
Clin Exp Immunol. 2002 Nov;130(2):169-71.

Twu C, Liu NQ, Popik W, Bukrinsky M, Sayre J, Roberts J, Rania S, Bramhandam V, Roos KP, MacLellan WR, Fiala M. 
Cardiomyocytes undergo apoptosis in human immunodeficiency virus cardiomyopathy through mitochondrion- and death receptor-controlled pathways.
Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14386-91.

Iordanskiy S, Iordanskaya T, Quivy V, Van Lint C, Bukrinsky M. 
B-oligomer of pertussis toxin inhibits HIV-1 LTR-driven transcription through suppression of NF-kappaB p65 subunit activity.
Virology. 2002 Oct 10;302(1):195-206.

Liu NQ, Lossinsky AS, Popik W, Li X, Gujuluva C, Kriederman B, Roberts J, Pushkarsky T, Bukrinsky M, Witte M, Weinand M, Fiala M. 
Human immunodeficiency virus type 1 enters brain microvascular endothelia by macropinocytosis dependent on lipid rafts and the mitogen-activated protein kinase signaling pathway.
J Virol. 2002 Jul;76(13):6689-700.

Bukrinsky MI. 
Cyclophilins: unexpected messengers in intercellular communications.
Trends Immunol. 2002 Jul;23(7):323-5. Review.

Yurchenko V, Zybarth G, O'Connor M, Dai WW, Franchin G, Hao T, Guo H, Hung HC, Toole B, Gallay P, Sherry B, Bukrinsky M. 
Active site residues of cyclophilin A are crucial for its signaling activity via CD147.
J Biol Chem. 2002 Jun 21;277(25):22959-65

Agostini I, Popov S, Hao T, Li JH, Dubrovsky L, Chaika O, Chaika N, Lewis R, Bukrinsky M. 
Phosphorylation of Vpr regulates HIV type 1 nuclear import and macrophage infection.
AIDS Res Hum Retroviruses. 2002 Mar 1;18(4):283-8.

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2001

Yurchenko V, O'Connor M, Dai WW, Guo H, Toole B, Sherry B, Bukrinsky M. 
CD147 is a signaling receptor for cyclophilin B.
Biochem Biophys Res Commun. 2001 Nov9;288(4):786-8.

Pushkarsky T, Zybarth G, Dubrovsky L, Yurchenko V, Tang H, Guo H, Toole B, Sherry B, Bukrinsky M. 
CD147 facilitates HIV-1 infection by interacting with virus-associated cyclophilin A.
Proc Natl Acad Sci U S A. 2001 May22;98(11):6360-5.

Gujuluva C, Burns AR, Pushkarsky T, Popik W, Berger O, Bukrinsky M, Graves MC, Fiala M. 
HIV-1 penetrates coronary artery endothelial cells by transcytosis.
Mol Med. 2001 Mar;7(3):169-76.

Alfano M, Vallanti G, Biswas P, Bovolenta C, Vicenzi E, Mantelli B, Pushkarsky T, Rappuoli R, Lazzarin A, Bukrinsky M, Poli G. 
The binding subunit of pertussis toxin inhibits HIV replication in human macrophages and virus expression in chronically infected promonocytic U1 cells.
J Immunol. 2001 Feb1;166(3):1863-70.

Fiala M, Gujuluva C, Berger O, Bukrinsky M, Kim KS, Graves MC. 
Chemokine receptors on brain endothelia--keys to HIV-1 neuroinvasion?
Adv Exp Med Biol. 2001;493:35-40. Review.

Pushkarsky T, Dubrovsky L, Bukrinsky M. 
Lipopolysaccharide stimulates HIV-1 entry and degradation in human macrophages.
J Endotoxin Res. 2001;7(4):271-6.

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2000

Agostini I, Popov S, Li J, Dubrovsky L, Hao T, Bukrinsky M. 
Heat-shock protein 70 can replace viral protein R of HIV-1 during nuclear import of the viral preintegration complex.
Exp Cell Res. 2000 Sep 15;259(2):398-403.

Alfano M, Pushkarsky T, Poli G, Bukrinsky M.
The B-oligomer of pertussis toxin inhibits human immunodeficiency virus type 1 replication at multiple stages.
J Virol. 2000 Sep;74(18):8767-70.

Glushakova S, Dubrovsky L, Grivel J, Haffar O, Bukrinsky M. 
Small molecule inhibitor of HIV-1 nuclear import suppresses HIV-1 replication in human lymphoid  tissue ex vivo: a potential addition to current anti-HIV drug repertoire.
Antiviral Res. 2000 Aug;47(2):89-95.

Haffar OK, Popov S, Dubrovsky L, Agostini I, Tang H, Pushkarsky T, Nadler SG, Bukrinsky M. 
Two nuclear localization signals in the HIV-1 matrix protein regulate nuclear import of the HIV-1 pre-integration complex.
J Mol Biol. 2000 Jun 2;299(2):359-68.

Sherry B, Schmidtmayerova H, Zybarth G, Dubrovsky L, Raabe T, Bukrinsky M.
Nitric oxide regulates MIP-1alpha expression in primary macrophages and T lymphocytes: implications for anti-HIV-1 response.
Mol Med. 2000 Jun;6(6):542-9.

Franchin G, Zybarth G, Dai WW, Dubrovsky L, Reiling N, Schmidtmayerova H, Bukrinsky M, Sherry B. 
Lipopolysaccharide inhibits HIV-1 infection of monocyte- derived macrophages through direct and sustained down-regulation of CC chemokine receptor 5.
J Immunol. 2000 Mar 1;164(5):2592-601.

1999

Viral protein R of HIV-1. 
M Bukrinsky 1, A Adzhubei 
Rev Med Virol. 1999 Jan-Mar;9(1):39-49.

Activation-induced resistance of human macrophages to HIV-1 infection in vitro
G Zybarth 1, N Reiling, H Schmidtmayerova, B Sherry, M Bukrinsky
J Immunol. 1999 Jan 1;162(1):400-6.

HIV-1 nuclear import: in search of a leader
M I Bukrinsky, O K Haffar  
Front Biosci. 1999 Oct 15:4:D772-81. doi: 10.2741/bukrinsky.

The B-oligomer of pertussis toxin deactivates CC chemokine receptor 5 and blocks entry of M-tropic HIV-1 strains
M Alfano, H Schmidtmayerova, C A Amella, T Pushkarsky, M Bukrinsky 
J Exp Med. 1999 Sep 6;190(5):597-605. doi: 10.1084/jem.190.5.597.

1998

HIV-1 nuclear import: matrix protein is back on center stage, this time together with Vpr
M I Bukrinsky, O K Haffar
Mol Med . 1998 Mar;4(3):138-43.

Viral protein R regulates nuclear import of the HIV-1 pre-integration complex
S Popov 1, M Rexach, G Zybarth, N Reiling, M A Lee, L Ratner, C M Lane, M S Moore, G Blobel, M Bukrinsky 
EMBO J. 1998 Feb 16;17(4):909-17. doi: 10.1093/emboj/17.4.909.

Bacterial lipopolysaccharide is a potent inhibitor of HIV-1 replication in T lymphocytes and macrophages
M Alfano, H Schmidtmayerova, M Bukrinsky
AIDS. 1998 Sep 10;12(13):1724-6.

Human immunodeficiency virus type 1 T-lymphotropic strains enter macrophages via a CD4- and CXCR4-mediated pathway: replication is restricted at a postentry level
H Schmidtmayerova 1, M Alfano, G Nuovo, M Bukrinsky 
J Virol. 1998 Jun;72(6):4633-42. doi: 10.1128/JVI.72.6.4633-4642.1998.

CNI-H0294, a nuclear importation inhibitor of the human immunodeficiency virus type 1 genome, abrogates virus replication in infected activated peripheral blood mononuclear cells
O K Haffar 1, M D Smithgall, S Popov, P Ulrich, A G Bruce, S G Nadler, A Cerami, M I Bukrinsky
Antimicrob Agents Chemother. 1998 May;42(5):1133-8. doi: 10.1128/AAC.42.5.1133.

Role of cyclophilin A in the uptake of HIV-1 by macrophages and T lymphocytes
B Sherry, G Zybarth, M Alfano, L Dubrovsky, R Mitchell, D Rich, P Ulrich, R Bucala, A Cerami, M Bukrinsky
Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1758-63. doi: 10.1073/pnas.95.4.1758.

Relative contribution of transcription and translation to the induction of tumor necrosis factor-alpha by lipopolysaccharide
T Raabe, M Bukrinsky, R A Currie 
J Biol Chem. 1998 Jan 9;273(2):974-80. doi: 10.1074/jbc.273.2.974.

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1997

HIV-1 nuclear import: in search of a leader
M I Bukrinsky 1, O K Haffar
Front Biosci . 1997 Dec 1:2:d578-87. doi: 10.2741/a213.

Cell proliferation is not required for productive HIV-1 infection of macrophages
H Schmidtmayerova 1, G J Nuovo, M Bukrinsky 
Virology. 1997 Jun 9;232(2):379-84. doi: 10.1006/viro.1997.8584.

The critical role of p38 MAP kinase in T cell HIV-1 replication
P S Cohen, H Schmidtmayerova, J Dennis, L Dubrovsky, B Sherry, H Wang, M Bukrinsky, K J Tracey 
Mol Med. 1997 May;3(5):339-46.

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1996

Chemokines and HIV replication
H Schmidtmayerova, B Sherry, M Bukrinsky 
Nature. 1996 Aug 29;382(6594):767. doi: 10.1038/382767a0.

Critical role of reverse transcriptase in the inhibitory mechanism of CNI-H0294 on HIV-1 nuclear translocation
S Popov 1, L Dubrovsky, M A Lee, S Pennathur, O Haffar, Y aL-Abed, P Tonge, P Ulrich, M Rexach, G Blobel, A Cerami, M Bukrinsky 
Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11859-64. doi: 10.1073/pnas.93.21.11859.

A critical role of nitric oxide in human immunodeficiency virus type 1-induced hyperresponsiveness of cultured monocytes
M Bukrinsky 1, H Schmidtmayerova, G Zybarth, L Dubrovsky, B Sherry, G Enikolopov 
Mol Med. 1996 Jul;2(4):460-8.

Cytokine-stimulated astrocytes damage human neurons via a nitric oxide mechanism
C C Chao 1, S Hu, W S Sheng, D Bu, M I Bukrinsky, P K Peterson
Glia. 1996 Mar;16(3):276-84. doi: 10.1002/(SICI)1098-1136(199603)16:3<276::AID-GLIA10>3.0.CO;2-X.

Suppression of proinflammatory cytokines in monocytes by a tetravalent guanylhydrazone
M Bianchi 1, O Bloom, T Raabe, P S Cohen, J Chesney, B Sherry, H Schmidtmayerova, T Calandra, X Zhang, M Bukrinsky, P Ulrich, A Cerami, K J Tracey 
J Exp Med. 1996 Mar 1;183(3):927-36. doi: 10.1084/jem.183.3.927.

Human immunodeficiency virus type 1 infection alters chemokine beta peptide expression in human monocytes: implications for recruitment of leukocytes into brain and lymph nodes
H Schmidtmayerova 1, H S Nottet, G Nuovo, T Raabe, C R Flanagan, L Dubrovsky, H E Gendelman, A Cerami, M Bukrinsky, B Sherry 
Proc Natl Acad Sci U S A. 1996 Jan 23;93(2):700-4. doi: 10.1073/pnas.93.2.700.

Anti-idiotypic antibody to the V3 domain of gp120 binds to vimentin: a possible role of intermediate filaments in the early steps of HIV-1 infection cycle
E K Thomas 1, R J Connelly, S Pennathur, L Dubrovsky, O K Haffar, M I Bukrinsky 
Viral Immunol. 1996;9(2):73-87. doi: 10.1089/vim.1996.9.73.

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1995

HIV results in the frame. Other approaches
M Bukrinsky, K Manogue, A Cerami
Comment Nature. 1995 May 18;375(6528):195-6; author reply 198. doi: 10.1038/375195b0.

An inhibitor of macrophage arginine transport and nitric oxide production (CNI-1493) prevents acute inflammation and endotoxin lethality
M Bianchi 1, P Ulrich, O Bloom, M Meistrell 3rd, G A Zimmerman, H Schmidtmayerova, M Bukrinsky, T Donnelley, R Bucala, B Sherry, et al.

Regulation of nitric oxide synthase activity in human immunodeficiency virus type 1 (HIV-1)-infected monocytes: implications for HIV-associated neurological disease
M I Bukrinsky 1, H S Nottet, H Schmidtmayerova, L Dubrovsky, C R Flanagan, M E Mullins, S A Lipton, H E Gendelman 
J Exp Med. 1995 Feb 1;181(2):735-45. doi: 10.1084/jem.181.2.735.

Nuclear localization signal of HIV-1 as a novel target for therapeutic intervention
L Dubrovsky 1, P Ulrich, G J Nuovo, K R Manogue, A Cerami, M Bukrinsky
Mol Med. 1995 Jan;1(2):217-30.
 

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1994

The neuropathogenesis of HIV-1 infection 
H E Gendelman, S A Lipton, M Tardieu, M I Bukrinsky, H S Nottet 
J Leukoc Biol. 1994 Sep;56(3):389-98. doi: 10.1002/jlb.56.3.389.

The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells
N K Heinzinger 1, M I Bukrinsky, S A Haggerty, A M Ragland, V Kewalramani, M A Lee, H E Gendelman, L Ratner, M Stevenson, M Emerman 
Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):7311-5. doi: 10.1073/pnas.91.15.7311.

Reduced nuclear import of human immunodeficiency virus type 1 preintegration complexes in the presence of a prototypic nuclear targeting signal
J Gulizia 1, M P Dempsey, N Sharova, M I Bukrinsky, L Spitz, D Goldfarb, M Stevenson 
J Virol. 1994 Mar;68(3):2021-5. doi: 10.1128/JVI.68.3.2021-2025.1994.
 

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1993

A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells
M I Bukrinsky 1, S Haggerty, M P Dempsey, N Sharova, A Adzhubel, L Spitz, P Lewis, D Goldfarb, M Emerman, M Stevenson
Nature . 1993 Oct 14;365(6447):666-9. doi: 10.1038/365666a0.

Human immunodeficiency virus type 1 2-LTR circles reside in a nucleoprotein complex which is different from the preintegration complex
M Bukrinsky 1, N Sharova, M Stevenson 
J Virol. 1993 Nov;67(11):6863-5. doi: 10.1128/JVI.67.11.6863-6865.1993.

Association of integrase, matrix, and reverse transcriptase antigens of human immunodeficiency virus type 1 with viral nucleic acids following acute infection
M I Bukrinsky 1, N Sharova, T L McDonald, T Pushkarskaya, W G Tarpley, M Stevenson 
Proc Natl Acad Sci U S A. 1993 Jul 1;90(13):6125-9. doi: 10.1073/pnas.90.13.6125.

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1992

HIV-1 replication and potential targets for intervention
M Stevenson 1, M Bukrinsky, S Haggerty
AIDS Res Hum Retroviruses. 1992 Feb;8(2):107-17. doi: 10.1089/aid.1992.8.107.

Active nuclear import of human immunodeficiency virus type 1 preintegration complexes
M I Bukrinsky 1, N Sharova, M P Dempsey, T L Stanwick, A G Bukrinskaya, S Haggerty, M Stevenson 
Proc Natl Acad Sci U S A. 1992 Jul 15;89(14):6580-4. doi: 10.1073/pnas.89.14.6580.

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1991

Quiescent T lymphocytes as an inducible virus reservoir in HIV-1 infection
M I Bukrinsky 1, T L Stanwick, M P Dempsey, M Stevenson
Science . 1991 Oct 18;254(5030):423-7. doi: 10.1126/science.1925601.

Posttranslational modifications within the HIV-1 envelope glycoprotein which restrict virus assembly and CD4-dependent infection
S Haggerty 1, M P Dempsey, M I Bukrinsky, L Guo, M Stevenson 
AIDS Res Hum Retroviruses. 1991 Jun;7(6):501-10. doi: 10.1089/aid.1991.7.501.

Highly immunogenic human immunodeficiency viruslike particles are produced by recombinant vaccinia virus-infected cells
A N Vzorov 1, M I Bukrinsky, V B Grigoriev, Tentsov YYu, A G Bukrinskaya
AIDS Res Hum Retroviruses. 1991 Jan;7(1):29-36. doi: 10.1089/aid.1991.7.29.

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1990

Plus strand of the HIV provirus DNA is expressed at early stages of infection
M I Bukrinsky, A F Etkin
AIDS Res Hum Retroviruses . 1990 Apr;6(4):425-6. doi: 10.1089/aid.1990.6.425.

Intracellular localization of recombinant vaccinia virus produced HIV antigens and their use for confirmation of HIV seropositivity
M I Bukrinsky 1, A N Vzorov, A G Bukrinskaya 
Acta Virol. 1990 Sep;34(5):487-92.

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1989

Heterogeneity of the ARV-2 strain and natural isolates of the human immunodeficiency virus
A F Etkin 1, M I Bukrinsky
Arch Virol. 1989;108(3-4):271-7. doi: 10.1007/BF01310939.

False-positive sera do not react with human immunodeficiency virus (HIV) gag-encoded recombinant antigen
M I Bukrinsky 1, V A Syrtsev, S A Popov, E V Barsov, S A Chaplinskas, E V Karamov
J Med Virol. 1989 Jan;27(1):72-5. doi: 10.1002/jmv.1890270115.

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1988

Multicopy expression vector based on temperature-regulated lac repressor: expression of human immunodeficiency virus env gene in Escherichia coli
M I Bukrinsky 1, E V Barsov, A A Shilov
Gene. 1988 Oct 30;70(2):415-7. doi: 10.1016/0378-1119(88)90215-6.

Reactivity to gag- and env-related proteins in immunoblot assay is not necessarily indicative of HIV infection
M I Bukrinsky, S A Chaplinskas, V A Syrtsev, L A Bravkilene, Y V Philippov
AIDS. 1988 Oct;2(5):405-6. doi: 10.1097/00002030-198810000-00019.

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